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O2–02–05: FDDNP‐PET binding values from cortical hemispheric surface maps correlate with MMSE scores
Author(s) -
Small Gary W.,
Protas Hillary D.,
Huang S.C.,
Kepe Vladimir,
Siddarth Prabha,
Hayashi Kiralee,
Klunder Andrea,
Braskie Meredith,
Ercoli Linda M.,
Bookheimer Susan Y.,
Thompson Paul M.,
Barrio Jorge R.
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2007.04.039
Subject(s) - nuclear medicine , cognitive impairment , senile plaques , neuroscience , alzheimer's disease , cognition , pathology , psychology , medicine , disease
3 outcome categories were randomly selected from the published study (Prichep, et al., Neurobiol Aging, 2006, 27:471-481) subject pool. From the baseline recordings, sLORETA analyses of the sources of surface electrical activity were performed and expressed using images for maximal theta frequency. Results: Highly significant differences (p 0.01) in maximal theta frequency are seen at baseline between the three outcome groups (see Figure). Progressive increments in maximal theta frequency in specific brain regions are seen with the following outcome hierarchy: NL/SCI MCI dementia. Conclusion: It appears that outcome in normal older subjects approximately a decade later, in terms of stability, decline to MCI, or conversion to dementia, can be predicted using these noninvasive, inexpensive, expeditious sLORETA procedures. These findings have significant import for prevention studies and the understanding of AD origins.