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Greater frequency of subcortical lesions in severely demented patients with early onset Alzheimer's disease
Author(s) -
Geppert Anita Malgorzata,
Wroblewska Katarzyna Anna,
Przedpelska-Ober Elzbieta Maria
Publication year - 2007
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.10.007
Subject(s) - magnetic resonance imaging , medicine , concomitant , disease , neuroimaging , alzheimer's disease , pathology , dementia , age of onset , cognitive decline , early onset alzheimer's disease , stroke (engine) , cardiology , radiology , psychiatry , mechanical engineering , engineering
Background Recent data have shown that in the early stages of Alzheimer's disease (AD), vascular brain lesions might promote the progression of cognitive decline or might even precede neuronal damage. Methods Ischemic brain lesions, recognized on computed tomography or magnetic resonance imaging, were analyzed retrospectively in 72 patients with early and late onset sporadic AD. Results All types of ischemic lesions occurred more frequently in the AD patients than in the controls. Analysis of subgroups of early and late onset AD patients diagnosed by magnetic resonance imaging showed a more frequent occurrence of subcoritcal lesions in severely demented patients with early onset AD. Conclusions The non‐stroke subcortical ischemic lesions occurring more frequently in our AD patients might be recognized as the concomitant vascular pathology that characterizes severely demented patients with early onset sporadic AD.