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P2–159: C4b–binding protein is present in cerebrospinal fluid from dementia patients
Author(s) -
Nielsen Henrietta M.,
Trouw Leendert,
Blom Anna,
Minthon Lennart,
Londos Elisabet,
Janciauskiene Sabina
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.997
Subject(s) - cerebrospinal fluid , neuroinflammation , complement system , dementia , vascular dementia , medicine , microglia , inflammation , immunology , pathology , disease , antibody
The sensitivity for detection of DLB was 81% with a specificity of 71% and 70% among PDD and a combined group (AD, PDD and NDC), respectively. Conclusions: Interestingly, DLB and PDD exhibit distinct clinical temporal course of disease accompanied by distinct neurochemical phenotypes in CSF, despite their similar neuropathological appearance. Despite some overlap, especially with regard to AD and DLB, the distinct neurochemical phenotypes in CSF indicate disease-specific interactions of each ongoing neurodegenerative dementia process with APP metabolism in AD, DLB and PDD. The evaluation of CSF A peptide patterns come closest to the requirements for a biomarker candidate and may be promising for future use in multiparametric approaches towards the differential diagnosis of dementias.