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P2–158: Cognitive decline and longitudinal measurements of CSF tau and AB42
Author(s) -
Andersson Christin,
Blennow Kaj,
Lindau Maria,
Almkvist Ove,
Engfeldt Peter,
Erik Johansson Sven,
Eriksdotter-Jönhagen Maria
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.996
Subject(s) - medicine , neuropsychology , cognitive decline , longitudinal study , cognition , psychology , alzheimer's disease neuroimaging initiative , disease , gastroenterology , cardiology , alzheimer's disease , dementia , pathology , neuroscience
The sensitivity for detection of DLB was 81% with a specificity of 71% and 70% among PDD and a combined group (AD, PDD and NDC), respectively. Conclusions: Interestingly, DLB and PDD exhibit distinct clinical temporal course of disease accompanied by distinct neurochemical phenotypes in CSF, despite their similar neuropathological appearance. Despite some overlap, especially with regard to AD and DLB, the distinct neurochemical phenotypes in CSF indicate disease-specific interactions of each ongoing neurodegenerative dementia process with APP metabolism in AD, DLB and PDD. The evaluation of CSF A peptide patterns come closest to the requirements for a biomarker candidate and may be promising for future use in multiparametric approaches towards the differential diagnosis of dementias.