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P2–092: Alcohol use does not influence longitudinal course of Alzheimer disease
Author(s) -
Williams Monique M.,
Storandt Martha,
Solipuram Arun K.,
Morris John C.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.929
Subject(s) - confounding , longitudinal study , alcohol , psychology , epidemiology , dementia , medicine , alzheimer's disease , clinical dementia rating , gerontology , disease , pathology , biochemistry , chemistry
positive and negative likelihood ratios (LRs) were calculated for IADL cutoffs from 8 to 13. Highest sensitivity (87%) was achieved with IADL 13; highest specificity (93%) was achieved with IADL 8. Positive and negative LRs at each cutoff were moderate or small: highest LR 2.78 at IADL 8; highest LR0.36 at IADL 13. Receiver operating characteristic (ROC) curve for IADL scores was constructed; diagnostic accuracy (area under the curve) was 0.63 (where 0.5 no added information, 1 perfect discrimination). Conclusions: Preliminary data suggest that IADL Scale scores have little contribution to make to the diagnosis of dementia in this clinic population (the study will continue for a further year). Nevertheless, IADL Scale scores may help with assessment of care needs and planning of appropriate care interventions.