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P2–085: Does pure vascular dementia exist or not? Correlation between WML and cognitive profile in demented patients
Author(s) -
Pedraza Olga L.,
Reyes Pablo,
Arango Gabriel,
Iragorri Angela M.,
Gil Fabián,
Sánchez Erick
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.922
Subject(s) - dementia , hyperintensity , vascular dementia , verbal fluency test , neuropsychology , leukoaraiosis , psychology , cognitive decline , frontotemporal dementia , audiology , cognition , boston naming test , neurology , psychiatry , medicine , disease , magnetic resonance imaging , radiology
Background: Most authors that measure WML in vascular dementia, correlate the severity of lesions with cognitive decline. In a previous study we suggested that demented patients, with stroke history have a cognitive profile of Alzheimer disease and that stroke is only a trigger of dementia. Objective(s): To determine if the white matter lesion (WML) volume, of demented patients, correlates with the cognitive decline profile. Methods: Thirty eight patients with dementia diagnosis, according the NINCDSADRDA and DSM IV criteria for Alzheimer Disease (AD), mild Cognitive impairment (MCI) and Frontotemporal dementia (FTD) went through a consensus diagnosis (Neurology, Geriatric, Psychiatry, and Neuropsychology) in San Ignacio Hospital Memory Clinic. The neuropsychological profile was evaluated with: verbal memory (Grober and Buschke), attention (TMT-A, symbol-digit), verbal fluency (FAS) and praxis (REY figure copy) tests. The patients with MRI that exhibited infarct were excluded. The WML volume was measured by hand with OSIRIS software by a blind evaluator. We correlated the total volume lesion and the cognitive profile using Wilcoxon rank-sum (alpha 0.05), performing in the stata 9.1 software. Results: We didn’t find correlation between WML and cognitive profile evaluated, except for the phonological fluency (p 0.05), suggesting frontal dysfunction, according to previous studies. Conclusions: The global cognitive decline of patients in this study, not limited to phonologic fluency, encourage us to pursuit a study to evaluate the hypothesis that suggests, that vascular lesions in demented patients, are probably parallel physiopathological findings but not the main cause of dementia.