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P2–071: Serum albumin level and cognitive decline in elderly patients after hip fracture
Author(s) -
Mizrahi Eliyahu H.,
Blumstein Tzvia,
Adunsky Abraham
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.908
Subject(s) - medicine , confounding , logistic regression , hip fracture , albumin , odds ratio , serum albumin , cognition , gastroenterology , psychiatry , osteoporosis
the modulator. Plasma A 40 was affected by -secretase inhibitors and was dependent on compound potency, dose and time after dosing; -secretase modulator had no effect on plasma A 40. As has been observed in humans and other preclinical species, plasma A 40 elevated above baseline after -secretase inhibition; time and extent of ‘overshoot‘ was dependent upon potency and dose. Conclusion: These comparative results highlight the opportunity to evaluate the amyloid hypothesis with varied mechanisms. CMP rhesus monkey studies are ongoing to address scientific (CSF Proteomics) and development (formulations, dosing regimes) questions with diverse compounds and to establish proof of concept with novel targets.