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P2–067: Protein targets involved in the mechanisms of cell death induced by an amyloid precursor protein cytoplasmic subdomain
Author(s) -
Madeira Alexandra,
Pommet Jean-Michel,
Prochiantz Alain,
Pimplikar Sanjay W.,
Allinquant Bernadette
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.904
Subject(s) - programmed cell death , amyloid precursor protein , biotinylation , cytoplasm , biology , microbiology and biotechnology , protein tyrosine phosphatase , phosphorylation , apoptosis , biochemistry , alzheimer's disease , medicine , disease , pathology
GFAP and light expressed in microglia cells, while there were large granular staining for synaptophysin around both GFAP containing cells and activated microglia. These results indicate that distinct changes occur in both types of synaptic components associated with A deposit and thus the punctuate increase in synaptophysin and chromogranin A immunoreactivities associated with A deposit and with reactive microglia might reflecting neuronal dysfunction.