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P2–007: Functional and physiological cholinergic deficits in the aged dog: Extending the canine model of dementia and Alzheimer's disease
Author(s) -
Araujo Joseph A.,
Nobrega Jose N.,
Raymond Roger,
Milgram Norton W.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.844
Subject(s) - cholinergic , arecoline , medicine , muscarinic acetylcholine receptor , dementia , neuropathology , psychology , disease , receptor
DEX) can exacerbate AD-like pathology, altering APP metabolism, in rats receiving infusion of A 1-40. Methods: 14 month-old aged rats were exposed to one-month unpredictable stress model before received intracerebroventricular infusion of A 140 or the combination of A 140 with DEX by miniosmotic pumps stereotaxically placed. Results: We found that rats exposed to either chronic unpredictable stress or DEX show an exaggeration of AD-like pathology induced by concurrent administration of A 1-40 via the intracerebroventricular route. All these individual and combined treatments resulted in marked changes in APP synthesis and processing which were accompanied by disruption of hippocampus-dependent functions such as exploratory behavior and spatial memory. Conclusions: These results support the hypothesis of stress as risk factor for AD pathogenesis.