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P2–003: Effects of antibiotic treatment on cellular inflammatory processes in the brain during persistent Chlamydia pneumoniae infection of BALB/c mice
Author(s) -
Hammond Christine J.,
Little C. Scott,
Longo Nicole,
Procacci Christina,
Appelt Denah M.,
Balin Brian J.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.840
Subject(s) - chlamydophila pneumoniae , microglia , chlamydia , immunology , neuroinflammation , antibiotics , inflammation , medicine , immune system , respiratory infection , biology , pathology , microbiology and biotechnology , respiratory system , chlamydiaceae
upon symptoms in the Mood cluster at both weeks 12 (P .034) and 24 (P .033), with 65.5% of patients in the memantine group showing a positive response at week 24. Memantine also had a significant effect over placebo (OC) upon symptoms of Psychosis at both weeks 12 (P .006) and 24 (P .001), with 80.7% of patients in the memantine group showing a positive response in this domain at week 24. The response difference (OC) between memantine and placebo patients at week 24 was 12.2% and 18.9% for Mood and Psychosis clusters, respectively. LOCF analysis yielded comparable results. Effects of memantine on Frontal symptoms were not significant, while the effects on Other symptoms were significant at week 24 using LOCF analysis (P .037), but not OC analysis (P .058). Conclusions: Taken together, these results suggest that memantine provides specific behavioral benefits for mood and psychosis-related symptoms associated with AD.