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P1–454: The effect of chronic administration of Withania somnifera on learning and memory deficits of diabetic rats
Author(s) -
Roghani Mehrdad,
Khalili Mohsen,
Mahdavi Fatemeh
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.833
Subject(s) - withania somnifera , diabetes mellitus , medicine , streptozotocin , oral administration , type 2 diabetes , nootropic , traditional medicine , pharmacology , endocrinology , pathology , alternative medicine
(STZ) in rats is followed by long-term and progressive deficits in learning, memory, and cognitive performance in rats that is somewhat similar to sporadic Alzheimer’s disease (SAD). Epidemiological studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) could delay or slow the clinical expression of SAD. Objective(s): Therefore, the beneficial effect of mefenamic acid (MA) was investigated on ICV STZ-induced learning, memory, and cognitive impairment in male rats. Methods: For this purpose, rats were injected with ICV STZ bilaterally, on days 1 and 3 (3 mg/kg). The STZ-injected rats received MA (30 mg/kg/day, i.p.) starting from day 5 post-surgery for two weeks. The learning and memory performance was assessed using passive avoidance paradigm, and for spatial cognition evaluation, radial eight-arm maze (RAM) task was used. Results: It was found out that MA-treated STZ-injected rats show higher correct choices and lower errors in RAM than vehicle-treated STZ-injected rats. In addition, MA administration significantly attenuated learning and memory impairment in treated STZ-injected group in passive avoidance test. Conclusions: These results demonstrate MA efficacy against cognitive deficits as well as learning and memory impairment caused by ICV injection of STZ in rats and its potential in the treatment of some neurodegenerative disorders including SAD.