Premium
P1–414: DNA decoy intervention of BACE1 synthesis in the guinea pig brain: A therapeutic approach
Author(s) -
Ferrari Diana C.,
Bourne Krystyn Z.,
Perez-Polo J. Regino
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.793
Subject(s) - western blot , cholinergic neuron , basal forebrain , guinea pig , decoy , hippocampal formation , nerve growth factor , cholinergic , microbiology and biotechnology , hippocampus , amyloid precursor protein , nf κb , biology , endocrinology , medicine , alzheimer's disease , receptor , biochemistry , signal transduction , disease , gene
(GSK-3), which is both a candidate tau kinase and an APP kinase, it is possible that a relative failure of insulin signalling might directly increase the pathological molecular processes of AD. In order to determine if insulin signalling was altered in AD, we aimed to map the expression and activity of proteins on the insulin signalling pathway from diseased and elderly control post-mortem brain samples.