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P1–403: Modulation of secretases by all–trans retinoic acid is directed by cPKCs
Author(s) -
Koryakina Anna,
Kiefer Sabine,
Küenzi Peter,
Hamburger Matthias O.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.782
Subject(s) - retinoic acid , amyloid precursor protein secretase , amyloid precursor protein , extracellular , chemistry , transcription factor , microbiology and biotechnology , downregulation and upregulation , biology , biochemistry , alzheimer's disease , medicine , gene , disease
Furthermore, we show that the ATRA-induced regulation of amyloidsecretases is shaped by the activity of conventional PKCs, notably PKC (upregulation) and PKC II in IMR-32 cells, which results in lowered DNA-binding activity of the transcription factor AP-1 but increased binding activity of NFB. In N2a cells, on the other hand, cPKCs are not affected but nevertheless show enhanced NFB as well as enhanced AP-1 binding activity.
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