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P1–312: Successful replication of association between late–onset Alzheimer's disease and the Insulin degrading enzyme (IDE)
Author(s) -
Björk Behnosh Fakhri,
Katzov Hagit,
Kehoe Patrick,
Fratiglioni Laura,
Winblad Bengt,
Prince Jonathan A.,
Graff Caroline
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.690
Subject(s) - insulin degrading enzyme , apolipoprotein e , allele , population , disease , amyloid (mycology) , genetics , biology , genetic association , gene , genotyping , presenilin , alzheimer's disease , insulin , medicine , genotype , single nucleotide polymorphism , endocrinology , pathology , environmental health
The common apolipoprotein E (APOE) e4 allele is strongly associated with risk of dementia and age at onset, but studies are inconclusive as to whether the e4 allele affects rate of progression or survival in demented patients. Furthermore, previous observations suggest a contribution of two APOE promoter polymorphisms (-491 A/T and -219 G/T) in dementia, but the influence of these two polymorphisms on survival in demented patients have not been evaluated yet.