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P1–294: Genetic association between PCSK9 and USF1 polymorphisms and Japanese Alzheimer's disease and plasma cholesterol level
Author(s) -
Shibata Nobuto,
Ohnuma Tohru,
Usui Chie,
Ohkubo Taku,
Watanabe Tomoko,
Kawashima Ritsuko,
Kitajima Akiyoshi,
Miyakawa Koichi,
Ueki Akira,
Arai Heii
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.671
Subject(s) - pcsk9 , single nucleotide polymorphism , kexin , biology , cholesterol , genetics , medicine , endocrinology , ldl receptor , gene , genotype , lipoprotein
(p .001) Apo 3/ 3 genotype was found in 23.08% of the control group against 14.12% in the patients group (p .001). No statistical differences were found in the isoforms 3/ 4 and 2/ 4. No statistical relevance was found with the only individual with the 2/ 2 isoform. Conclusions: Genotype 4/ 4 of apolipoprotein E has a greater prevalence in patients with Alzheimer’s disease confirming our working hypothesis. There is an important association between ApoE 4 as risk factor of Alzheimer’s disease in addition to clinical and diagnosis skills.