P1–294: Genetic association between PCSK9 and USF1 polymorphisms and Japanese Alzheimer's disease and plasma cholesterol level | Zendy

Shibata Nobuto | Zendy; Ohnuma Tohru | Zendy; Usui Chie | Zendy; Ohkubo Taku | Zendy; Watanabe Tomoko | Zendy; Kawashima Ritsuko | Zendy; Kitajima Akiyoshi | Zendy; Miyakawa Koichi | Zendy; Ueki Akira | Zendy; Arai Heii | Zendy

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P1–294: Genetic association between PCSK9 and USF1 polymorphisms and Japanese Alzheimer's disease and plasma cholesterol level

Author(s) -

Shibata Nobuto,

Ohnuma Tohru,

Usui Chie,

Ohkubo Taku,

Watanabe Tomoko,

Kawashima Ritsuko,

Kitajima Akiyoshi,

Miyakawa Koichi,

Ueki Akira,

Arai Heii

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.671

Subject(s) - pcsk9 , single nucleotide polymorphism , kexin , biology , cholesterol , genetics , medicine , endocrinology , ldl receptor , gene , genotype , lipoprotein

(p .001) Apo 3/ 3 genotype was found in 23.08% of the control group against 14.12% in the patients group (p .001). No statistical differences were found in the isoforms 3/ 4 and 2/ 4. No statistical relevance was found with the only individual with the 2/ 2 isoform. Conclusions: Genotype 4/ 4 of apolipoprotein E has a greater prevalence in patients with Alzheimer’s disease confirming our working hypothesis. There is an important association between ApoE 4 as risk factor of Alzheimer’s disease in addition to clinical and diagnosis skills.

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