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P1–286: Dementia genetic risk factors and blood lipid parameters
Author(s) -
Fernandez-Novoa Lucia,
Seoane Silvia,
Corzo Lola,
Lombardi Valter R.M.,
Cacabelos Ramon
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.663
Subject(s) - apolipoprotein e , dementia , medicine , lipid profile , genotype , endocrinology , risk factor , cholesterol , gene , polymorphism (computer science) , biology , genetics , disease
Background: High cholesterol is generally considered a risk factor for dementia, and particularly dementia of the Alzheimer type (AD) although studies examining that connection have yielded conflicting results. Cholesterol influences the development of AD by affecting A formation and distribution within cholesterol membranes. Objective(s): We have investigated the influence of polymorphisms in genes related to AD risk development (APOE, A2M, AGT, ACE and NOS3) on the levels of lipid parameters and on vascular risk (VR), in Control subjects and AD patients. We also examined the interactive effect of these genes on lipid parameters and VR. Methods: A total of 732 subjects were included in the study, 299 Control and 433 AD. Patients were diagnosed according to NINCDSADRDA and DSM-IV criteria for clinically probable AD. Results: Our results indicate that APOE, ACE and NOS3 gene polymorphisms significantly influence lipid levels in Controls, while in AD the influence was observed in APOE, A2M and ACE genes. The effect of interactions between polymorphisms and lipid levels and VR was tested by the combined effect of two genotypes. In Controls, we found a modest interaction between APOE and NOS3 on CHOL and LDL, as well as between A2M and NOS3 on LDL, also we observed that ACE in combination with NOS3 has a small influence on VR. In AD subjects, we observed a modest influence between APOE and A2M on CHOL, between A2M and NOS3 on LDL and finally between APOE and ACE on VR. Conclusions: There are several polymorphisms in genes involved in AD risk development that significantly influence lipid parameters, in addition a modest interaction was observed between gene polymorphisms and lipid parameters.