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P1–279: Familial Alzheimer's disease: The NIA–LOAD study
Author(s) -
Mayeux Richard
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.656
Subject(s) - disease , gerontology , medicine , family medicine , pathology
We tested hypotheses that supplemental intake of coenzyme Q10 (CoQ10) could delay the brain atrophy in transgenic aged mice by volume MR image in vivo. 133 mice (37 APP/PS1, 24 APP, 36 PS1 and 36 wild type) with age of 496 days and weight of 29.92g were administered CoQ10 (1200mg/kg/day) and the vehicle (vegetable oil) via gavage for a period of 8 weeks. High-Performance Liquid Chromatography was used to test the tissue levels of CoQ10 and magnetic resonance images were used to obtain the volumes of the hemispheres and hippocampi. MRI was performed on a Philips Achiva 3T with a transmit/receive wrist coil. Parameters for PDW 3D TSE transverse brain images were TR 2000 ms, TE 26 ms, FOV 10 10 mm, Matrix scan 400 400, NSA 12, slice thickness 0.5 mm without slice gap. Regions of interest (ROIs) were manually drawn on whole volume of the hippocampus (H), hemisphere (HM), and intracranial volume using image processing software Analyze 6.0. In order to correct for normal size differences between animals, volume results were expressed as a ratio relative to the intracranial volume.