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P1–266: Modification of cognitive trajectories: NSAID use in the Cache County study
Author(s) -
Hayden Kathleen M.,
Zandi Peter P.,
Khachaturian Ara S.,
Pieper Carl F.,
Sanders Linda,
Ostbye Truls,
Tschanz JoAnn T.,
Norton Maria C.,
Munger Ronald,
Lyketsos Constantine G.,
Breitner John C.S.,
Welsh-Bohmer Kathleen A.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.643
Subject(s) - medicine , dementia , cognitive decline , cognition , cohort , population , epidemiology , cohort study , gerontology , mini–mental state examination , longitudinal study , demography , disease , psychiatry , environmental health , sociology , pathology
Background: Although AD is considered a degenerative disorder, changes involving main functions of the immune system have been observed. Objective(s): To investigate the signs of inflammatory processes in AD, peripheral blood mononuclear cells from a total of 84 AD patients were immunophenotyped by means of double-color flow cytometric analysis, and the results were compared with those for agematched healthy controls. Methods: The cell subsets quantified included total T cells (CD3 ), B cells (HLA-DR ), NK cells (CD56 ), CD4 and CD8 T cells, cytotoxic (CD28 ) and suppressor precursor (CD28) CD8 T cells, CD45RA and CD45RO T cells (CD4 and CD8 ), and CD7 T cells. Results: Analysis of AD patients’ peripheral blood revealed essentially normal levels of total T, B and NK cells. In agreement with results obtained by other groups, it was found that AD patients had an increased CD4/CD8 ratio, due to both a decrease in CD8 T cells and to an increase of CD4 T cells. AD patients were found to have a significantly decreased level of suppressor precursor (CD28) CD8 T cells and normal levels of cytotoxic (CD28 ) CD8 T cells compared with that of controls. These data indicate that AD patients do not have a general decrease in CD8 T cells but that they have a specific decrease in the suppressor precursor subset only and normal levels of cytotoxic CD8 T cells. AD patients also had a significant increase in memory (CD45RO ) T cells and displayed a trend towards a decrease in naı̈ve (CD45RA ) T cells in the peripheral blood. Conclusions: The observed dysfunction in immune peripheral cell subpopulations point to a reduction of suppressor cell function in AD patients.