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P1–260: The epidemiology of dementia in Galicia, Spain
Author(s) -
Mateos Raimundo,
Garcı́a-Mahı́a Carmen,
Ramos Ramón
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.637
Subject(s) - epidemiology , dementia , population , gerontology , medicine , depression (economics) , demography , environmental health , disease , pathology , sociology , economics , macroeconomics
Methods: The sample consisted of 264 participants with incident AD, identified through two waves of assessment (1998-1999 and 2002-2004). At each wave, symptoms were assessed using the Neuropsychiatric Inventory (NPI). Prior to the onset of dementia, a history of stroke, hypertension, hyperlipidemia, heart attack or CABG, and diabetes were recorded. Logistic regression procedures were used to examine the relationship of each vascular condition to individual neuropsychiatric symptoms. Covariates considered were age, gender, education, dementia severity, and overall health status. Results: Neuropsychiatric symptoms were frequent in AD (45.5%). Depression was the most common symptom (25.6%), followed by apathy (18.7%) and irritability (18.2%). Least common were elation (0.8%), hallucinations (5.8%), and disinhibition (6.6%). Results of the logistic regression analyses revealed stroke to be associated with increased risk of delusions (OR 4.44, CI(95) 1.28-15.35, p .02), depression (OR 3.29, CI(95) 1.02-10.69, p .05), and apathy (OR 3.90, CI(95) 1.1613.11, p .03). Hypertension was associated with increased risk of delusions (OR 2.70, CI(95) 1.36-5.37, p .005) and agitation/ aggression (OR 2.92, CI(95) 1.31-6.50, p .009). Significant age effects were observed for depression and apathy. Conclusions: These results suggest an increased risk of neuropsychiatric symptoms with history of stroke and hypertension, and may provide an avenue for reduction in occurrence through the treatment or prevention of these conditions.