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P1–252: Androgens regulate development of neuropathology in a mouse model of Alzheimer's disease
Author(s) -
Rosario Emily R.,
Carroll Jenna C.,
Chang Lilly,
Stanczyk Frank,
Oddo Salvatore,
LaFerla Frank,
Pike Christian J.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.629
Subject(s) - neuropathology , endocrinology , spontaneous alternation , medicine , androgen , hippocampus , hippocampal formation , testosterone (patch) , genetically modified mouse , dihydrotestosterone , pathogenesis , alzheimer's disease , neuroscience , psychology , disease , transgene , biology , hormone , biochemistry , gene
above 60 years of age was 1022 per 100,000, showing an exponential increase in prevalence rate with advancement of age. Age and sex specific prevalence rates showed progressive increase with advancement of age in both genders, but women were predominant sufferers above 75 years age. Of the dementia subtype, Alzheimer type dementia was 52%, vascular 39%, and others 9%. Conclusions: Compared to developed countries, the prevalence of dementia was much lower in our study despite a low literacy rate. In developing countries like India illiterate people are engaged in tasks that demand continuous cognitive exercise to earn their livelihood. This raises the question whether a formal academic achievement is important for protection against dementia.