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P1–237: Category verbal fluency: Normative data for the Brazilian elderly
Author(s) -
Barros Sergio B.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.614
Subject(s) - percentile , raw score , normative , verbal fluency test , psychology , population , fluency , demography , age groups , test (biology) , gerontology , developmental psychology , medicine , cognition , statistics , neuropsychology , mathematics , psychiatry , philosophy , epistemology , sociology , paleontology , mathematics education , biology
ods: The subjects were participants of the Uppsala Longitudinal Study of Adult Men (ULSAM), which started when they were 50 years old. In the present study, baseline data were collected from a follow-up at age 70 (n 888). Measurements included fasting plasma glucose, insulin, oral glucose tolerance test (OGTT) and peripheral insulin sensitivity estimated by the euglycemic clamp technique. EIR was based on 30 minutes data from the OGTT. Cognitive function was assessed three times during the follow-up and participants with signs of impairment underwent a detailed diagnostic workup. Additional cases of dementia were identified through medical records. By the end of 2005, median 11.6 years after baseline, 61 men had developed AD according to the NINCDS-ADRDA and DSM IV criteria. CT scans were consistent with the diagnosis. Associations were analyzed using Cox proportional hazard analyses. Results: We did not find any association between diabetes, insulin sensitivity and AD. In the non-diabetic subjects (n 798), however, a decreased early insulin response was associated with higher risk of AD (HR/1SD 1.30, CI 1.06-1.48, p 0.019). The same odds ratio was obtained after adjustment for the insulin sensitivity index (M/I ratio), APOE genotype, BMI, hypertension, total cholesterol and education level (HR/1SD 1.27, CI 0.99-1.47 p 0.054). Studies on the association between glucose metabolism and vascular dementia and MCI (mild cognitive impairment) are in progress. Conclusions: In this longitudinal study, insulin sensitivity measured by the euglycemic clamp technique was not associated with AD. An impaired early insulin response, a marker of -cell dysfunction, was associated with higher risk of AD even after adjustment for other risk factors.