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P1–232: Is low blood pressure a risk factor for dementia and Alzheimer's disease in the elderly?
Author(s) -
Qiu Chengxuan,
Winblad Bengt,
Fratiglioni Laura
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.609
Subject(s) - dementia , blood pressure , hazard ratio , medicine , risk factor , proportional hazards model , alzheimer's disease , cardiology , cohort , confounding , confidence interval , cohort study , disease
identify cases with AD and other cognitive disorders. We report results from those who still participated in the study at 70 years of age and participated in all baseline examinations (n 1054). Results and Discussion: In December 2005, 68 men had been diagnosed as AD according to the NINCDS-ADRDA and DSM-IV criteria, and with a CT scan consistent with this diagnosis. Another 11 men had AD with concomitant cerebrovascular disease or AD combined with vascular dementia, and 8 men were classified as mild cognitive impairment possibly due to AD. Baseline serum levels of beta carotene, alphatocopherol, selenium, retinol and proportions of fish fatty acids (EPA, 20:5 n-3 and DHA, 22:6 n-3) did not differ between those who had developed AD and the rest of the cohort. Serum beta carotene, selenium and DHA levels were higher in men with university education. Our results do not support the hypothesis that a ‘healthy diet‘ in midlife protects from late-life dementia.