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P1–221: Association between dementia and cancer
Author(s) -
Guidi Ilaria,
Galimberti Daniela,
Dobreea Andreea,
Corrà Barbara,
Tiriticco Marco,
Perego Laura,
Bonino Ferruccio,
Bresolin Nereo,
Scarpini Elio
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.598
Subject(s) - dementia , medicine , progressive supranuclear palsy , tauopathy , cancer , frontotemporal dementia , corticobasal degeneration , disease , medical history , cognitive decline , oncology , psychiatry , neurodegeneration
the number of episodes. Volumetric assessment of the hippocampus was performed using a 3-dimensional MRI sequence. Total hippocampal volumes were calculated with correction for head size and gender. Subjects with volumes below the 25th percentile of the distribution were defined as having a small hippocampus (n 128). All subjects were followed for development of AD. The diagnosis of AD was made according to internationally accepted criteria. Results: A history of depressive episodes was reported by 142 (27.8%) subjects, with 85 reporting one episode and 50 reporting 2 or more episodes. Logistic regression analyses adjusted for age, gender, education, memory complaints, and MMSE score, showed that subjects with a history of depression were less likely to have a small hippocampus than those without such a history (OR 0.63; 95%CI 0.381.05). The OR of having a small hippocampus associated with 1 episode versus none was 0.74 (95%CI 0.41-1.33) and 2 versus none 0.42 (95%CI 0.18-0.98) (p-trend 0.03). After an average of 6 years of follow-up, 34 subjects developed AD. Cox regression analyses with adjustment for the same covariates showed that subjects with a history of depression had an increased risk of AD (HR 2.42; 95%CI 1.15-5.10). The HR of AD associated with 1 episode versus none was 2.14 (95%CI 0.81-5.64), and 2 versus none 2.54 (95%CI 0.90-7.16) (p-trend 0.04). Conclusion: This study suggests that elderly with a history of depressive episodes are less likely to have a small hippocampus, whereas prospectively they have an increased risk of AD. If replicated, future research should investigate what mechanisms may underly these seemingly contradictory associations.