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P1–203: Depression in children of persons with Alzheimer's disease: The Wisconsin Registry for Alzheimer's prevention
Author(s) -
Sager Mark A.,
Hermann Bruce,
LaRue Asenath
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.580
Subject(s) - depression (economics) , dementia , disease , alzheimer's disease , medicine , psychology , psychiatry , stroop effect , clinical psychology , cognition , economics , macroeconomics
follow-up. In men, total testosterone was not associated with the risk of dementia, regardless of time-to-event. In line with these observations, total and bioavailable testosterone levels were not related to hippocampal or amygdalar atrophy on MRI. No associations were found in women. Additional adjustment for potential confounders or stratification by apolipoprotein E genotype or smoking did not markedly change the results. Conclusions: Higher bioavailable testosterone levels are associated with a decreased risk of imminent dementia and AD in elderly men, but not with the longer term risk of dementia. This suggests that low testosterone levels result from rather than contribute to AD.