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P1–185: Effect of intraperitoneal injection of LPS on tau hyperphosphorylation in rat hippocampus
Author(s) -
Hua Liu Ying,
Zhi Wang Jian
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.560
Subject(s) - hyperphosphorylation , intraperitoneal injection , phosphorylation , hippocampus , lipopolysaccharide , tau protein , inflammation , medicine , endocrinology , blot , chemistry , tauopathy , alzheimer's disease , biochemistry , neurodegeneration , disease , gene
cognitive performances after adjusting for confounders. To study simultaneously the influence of MDE and HighDS on cognition, we considered six groups of subjects : (No MDE,No HighDS) (No MDE, HighDS) (Past MDE,No HighDS) (Past MDE, HighDS) (Current MDE,No HighDS) (Current MDE, HighDS) and we compared cognitive performance across groups. Analyses revealed that whatever the MDE status (no, past, current), subjects with HighDS had significantly decreased cognitive performances than those without HighDS. The influence of HighDS on cognition did not differ according to MDE status. Conclusions: Our results do not support the hypothesis that MDE is a risk factor for cognitive impairment but rather suggest that HighDS is associated with significant cognitive dysfunction.