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P1–177: Total folate levels in Alzheimer disease and other forms of degenerative cognitive decline
Author(s) -
Lovati Carlo,
Bertora Pierluigi,
Galimberti Daniela,
Suardelli Massimo,
Mailland Enrico,
Rosa Silvia,
Capiluppi Elisa,
Vanotti Alessandra,
Pomati Simone,
Mariani Claudio
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.553
Subject(s) - dementia , hyperhomocysteinemia , medicine , alzheimer's disease , ageing , disease , folic acid , etiology , homocysteine , cognitive decline , gastroenterology
caregivers were interviewed for 34 demented subjects (29 AD), 108 MCI and 57 Normal. Mean (SE) MMSE scores were 20.6(3.1), 15.8(3.9) and 12.0(3.5), respectively for Normal, MCI and Dementia subjects(p 0.0001). Mean (SE) Blessed scores were 1.1(1.2), 1.6(1.5) and 4.3(2.8) for Normal, MCI and Dementia, respectively(p 0.0001). NPI symptoms were present in all groups. Significant differences were observed between the diagnoses in the severity of symptoms and distress experienced by the caregivers with delusion, depression (only severity), hallucination, disinhibiton, irritability and aberrant motor behavior (p 0.05 for all). Conclusions: Non-cognitive symptoms as measured by the NPI predate the onset of dementia and, as is the case with cognitive symptoms, cause the greatest impairment in demented subjects followed by MCI and least with those diagnosed normal. This has important implications for management of dementia and probably MCI. Acknowledgment: Supported by grant RO1AGO9956-14. The Indianapolis Research Project by National Institute on Aging.