P1–169: Clinical and neuropathologic studies of age–related cognitive loss in Mumbai, India

plasma A levels and body mass index (BMI) or fat mass (FM) in a group of 18 healthy adults. Results: A statistically significant correlation was found between BMI, FM, and plasma levels of A 42 (BMI r 0.602, P 0.008; FM r 0.547, P 0.019), the longer, more pathogenic form of A , but not with plasma levels of the shorter, less pathogenic A 40. Although not significant, positive correlations between plasma levels of A 42 and levels of insulin and the inflammatory marker C-reactive protein (CRP), along with an inverse trend between plasma A 42 levels and levels of high density lipoprotein (HDL), were answered. Conclusions: These results suggest that proteins implicated in inflammation, cardiovascular disease and type 2 diabetes, which in turn are risk factors for AD, may contribute to the associations between BMI/FM and plasma A 42 levels. Longitudinal studies involving larger cohorts are required to determine if elevated body fat may predispose individuals to AD through increasing A 42 levels throughout early to late adulthood. Abbreviations: AD, Alzheimer’s disease; A , amyloid-beta protein; APOE 4, Apolipoprotein E epsilon 4 allele; BMI, body mass index; CRP, Creactive protein.