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P1–160: Women who maintain optimal cognitive function into old age
Author(s) -
Barnes Deborah E.,
Cauley Jane A.,
Lui Li-Yung,
Fink Howard A.,
McCulloch Charles,
Stone Katie L.,
Yaffe Kristine
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.536
Subject(s) - cognition , cognitive decline , demography , medicine , effects of sleep deprivation on cognitive performance , gerontology , psychology , dementia , psychiatry , disease , sociology
OBJECTIVESTo determine whether older women who maintain optimal cognitive function into old age differ from those who experience minor cognitive decline typically associated with normal aging.DESIGNProspective cohort study.SETTINGThe Study of Osteoporotic Fractures.PARTICIPANTSNine thousand seven hundred four older women.MEASUREMENTSA modified Mini-Mental State Examination (mMMSE) was performed at baseline and Years 6, 8, 10, and 15. Random-effects regression was used to classify subjects as cognitive maintainers (slope>/=0), minor decliners (slope < 0 but > lowest tertile), or major decliners (slope