Premium
P1–144: qEEG in Alzheimer disease and control subjects: Longitudinal changes and possible follow–up of cognitive impairment
Author(s) -
Raicher Irina,
Takahashi Daniel Yasumasa,
Nitrini Ricardo,
Anghinah Renato
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.520
Subject(s) - dementia , electroencephalography , context (archaeology) , delirium , psychology , audiology , disease , cognition , longitudinal study , neurology , medicine , psychiatry , pathology , paleontology , biology
PD. However, the status of brain cholinergic function in the early stage of PD is not well known. Objective(s): To elucidate the status of brain cholinergic system in patients with early PD by PET. Methods: Participants were nine PD with disease duration less than three years (age 65 9, male:female 6:3, MMSE 28.1 2.0, Hoehn & Yahr stage 2.2 0.7), and 27 healthy volunteers (age 64 11, male:female 14:13, MMSE 29.4 1.0). Irreversible PET tracer N-[C] methylpiperidin-4yl acetate ([C]MP4A), an acetylcholine analogue, was chosen to measure acetylcholinesterase (AChE) activity, a marker of cholinergic function, in the brain. [C]MP4A PET acquisition was 40 minutes scan with 14 frames. A three compartment model was employed to estimate voxel-by-voxel k1, k2, and k3 in the whole brain using the arterial input function. The k3 value was used as an index of AChE activity. Group comparison of k3 values in healthy controls and PD patients was performed using two-sample t-test in SPM2 (uncorrected p 0.0001, cluster extent K 50 voxels). Results: Brain AChE activity was significantly decreased in temporal cortex and to a lesser degree in frontal, parietal, occipital, and middle cingulate cortices of early PD group, compared with control group. Conclusions: Cholinergic system is impaired from the early stage without any obvious cognitive deficit in PD.