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P1–134: The differences of hypometabolic area and neuropsychological abnormalities between transient global amnesia and Alzheimers' disease: A PET study
Author(s) -
Kwon Oh Dae,
Park Heuiceun
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.510
Subject(s) - transient global amnesia , neuropsychology , amnesia , statistical parametric mapping , neuropsychological test , medicine , alzheimer's disease , psychology , magnetic resonance imaging , audiology , pathology , radiology , neuroscience , cognition , disease , psychiatry
ing dementia cases. It is related to cognitive dysfunction, eye movement disorder and gait disturbance. Objectives: To emphasize the relation of eye movement disorder, gait disturbance, cognitive dysfunction and a possible nutritional deficit. Methods: A case was presented with memory problems, gait disturbance and imbalance. We followed patient clinically and available cognitive tests were done. Result: Her history revealed diagnosis of vitamin B12 deficiency before admission and IM replacement treatment. Neurological examination revealed bilateral internuclear ophthalmoplegia (INO), diminished deep tendon reflexes, impaired position and vibration sense in lower extremities, positive Romberg sign, ataxic gait. Cognitive tests including formed digit span, ten word list learning, recall and recognition, clock drawing, short version of Boston naming test, praxis tests, visuo-construction tests were within normal limits. MMSE score was 28. All daily activities were peformed normally. Magnetic resonance imaging showed hyperintense lesions in pons possibly due to demyelinization caused by vitamin B12 deficiency. Patient received vitamin B12 replacement. But her INO and disturbance of gait persisted. Conclusion: Vitamin B12 deficiency is common in elderly and may cause gait disturbance and eye movement disorder without causing a cognitive dysfunction.