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P1–111: Using a Drosophila model of Alzheimer's disease to identify genetic modifiers of Ab1–42–induced oxidative stress
Author(s) -
Rival Thomas,
Crowther Damian C.,
Richard Page,
Ed Ryder,
Rosa Bautista-Llacer,
Lomas Lomas A.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.487
Subject(s) - drosophila melanogaster , neurodegeneration , biology , oxidative stress , phenotype , gene , gene knockdown , genetics , neuroprotection , microbiology and biotechnology , disease , neuroscience , biochemistry , medicine , pathology
Reelin in the brain. Western blot analysis of the hippocampus, which receives projections from the entorhinal cortex, revealed significant reductions in Reelin levels in this region. In contrast, the number of Reelinexpressing GABAergic interneurons was not altered in either the entorhinal cortex or the hippocampus. Conclusions: These results demonstrate that in a transgenic mouse model of AD, a specific population of entorhinal cortical pyramidal neurons is either lost or exhibits reduced expression of Reelin, a molecule with important roles in regulating tau phosphorylation as well as synaptic plasticity. These findings support the hypothesis that alterations in Reelin processing or signaling may be involved in AD-related neuronal dysfunction.