Premium
P1–033: The identification of distinct pools of Aβ in the brains of TASTPM mice
Author(s) -
Hussain Ishrut,
Hawkins Julie,
Harrison David,
Collier Sarah,
Vinson Mary,
Burbidge Steve A.,
Davis John B.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.408
Subject(s) - western blot , guanidine , gel electrophoresis , genetically modified mouse , chemistry , blot , extracellular , microbiology and biotechnology , sodium , biology , biochemistry , transgene , gene , organic chemistry
compared to controls. BDNF mRNA levels were also significantly reduced in 15-18 month old APP and APP/PS-1 mice, but not in mice carrying only the PS-1 mutation. BDNF levels were unchanged in 18-21 month old Ts65Dn mice compared to controls, indicating that over-expression of murine APP without mutation is insufficient to down-regulate BDNF, and that defective retrograde transport in these mice, which is known to result in accumulation of NGF in cholinergic target tissues, does not influence cortical BDNF mRNA levels. In summary, mutation(s) in APP alone are sufficient to down-regulate BDNF mRNA in cortical tissue of transgenic mice.