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P1–027: Assessment of the consequences of noradrenaline manipulation in the APP/PS1 mutant TASTPM mouse
Author(s) -
Sunter David,
Pugh Perdita,
Vidgeon-Hart Martin P.,
Ashmeade Tracey,
Culbert Ainsley,
Seymour Zoe,
Bate Simon,
Babin Anna,
Virley David,
Upton Neil
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.402
Subject(s) - neuroinflammation , locus coeruleus , tyrosine hydroxylase , hippocampus , amyloid precursor protein , chemistry , endocrinology , medicine , alzheimer's disease , inflammation , immunohistochemistry , central nervous system , disease
before and directly after bolus injection of ultra small paramagnetic particles of iron oxide (USPIO). With deuterium magnetic resonance spectroscopy (MRS) techniques, rCBV of the whole brain was determined. Further, A , sterol and fatty acid levels were determined in brain tissue. Results: Results show that a diet enriched with 1% cholesterol increases A plaque burden in the dentate gyrus of the hippocampus of 19 months old APP/PS1 mice, and in addition also tends to decrease rCBV of these TWD(t) mice. No changes in fatty acid profiles or cholesterol could be observed in brain tissue, whereas a DHA diet significantly increased cortex rCBV and the n3 fatty acid concentration, indicating increased membrane fluidity. Conclusions: Together these results suggest that changes in hemodynamics, such as rCBV, show association with amyloid deposition, indicating a more solid ground for AD as a vascular disorder. To elucidate these findings, experiments are repeated earlier in the course of the disease (8 and 15 months) to strengthen the present results and hypothesis. Except rCBV and Alzheimer’s pathology, cognitive/behavioural studies will be exerted as well.