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P1–003: Thiorphan infusion induces deposition of beta–amyloid in PDAPP transgenic mice
Author(s) -
Bales Kelly R.,
DeLong Cynthia,
Wu Su,
Koger Deanna
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.378
Subject(s) - thiorphan , neprilysin , medicine , endocrinology , genetically modified mouse , hippocampus , chemistry , transgene , biochemistry , gene , enzyme
significant neuronal cell loss is observed but where spatial reference memory displays variable deficits. Conclusion: The memory deficits in the rTg4510 mice appear to result from changes in neuronal function rather than overall neuronal death. Initial results suggest that synaptic degeneration pre-dates neuronal loss by several months. We therefore hypothesize that memory deficits in rTg4510 mice may be due at least in part to a synaptic disorder that is reversible upon suppression of mutant tau.