P1–003: Thiorphan infusion induces deposition of beta–amyloid in PDAPP transgenic mice | Zendy

Bales Kelly R. | Zendy; DeLong Cynthia | Zendy; Wu Su | Zendy; Koger Deanna | Zendy

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P1–003: Thiorphan infusion induces deposition of beta–amyloid in PDAPP transgenic mice

Author(s) -

Bales Kelly R.,

DeLong Cynthia,

Wu Su,

Koger Deanna

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.378

Subject(s) - thiorphan , neprilysin , medicine , endocrinology , genetically modified mouse , hippocampus , chemistry , transgene , biochemistry , gene , enzyme

significant neuronal cell loss is observed but where spatial reference memory displays variable deficits. Conclusion: The memory deficits in the rTg4510 mice appear to result from changes in neuronal function rather than overall neuronal death. Initial results suggest that synaptic degeneration pre-dates neuronal loss by several months. We therefore hypothesize that memory deficits in rTg4510 mice may be due at least in part to a synaptic disorder that is reversible upon suppression of mutant tau.

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