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O1–04–02: Brain cortical thickness in an FTD3 patient and mutation carriers
Author(s) -
Johannsen Peter,
Eskildsen Simon F.,
Nielsen Jørgen,
Fisher Elizabeth,
Zeidler Dora,
Rodell Anders,
Østergaard Leif
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.246
Subject(s) - mutation , cortex (anatomy) , neuroimaging , exon , statistical parametric mapping , medicine , biology , genetics , gene , neuroscience , magnetic resonance imaging , radiology
pathology. Objectives: This study is to investigate the association between visual hallucinations in patients with Alzheimer’s (AD) and/or Lewy body pathology. Method: Clinical assessments were conducted as part of the University of Washington/Group Health Cooperative Alzheimer’s Disease Patient Registry on an annual basis. Each subject underwent detailed neuropsychiatric and cognitive assessments. A subset of subjects agreed to autopsy. All autopsied material underwent a standard neuropathological (np) examination. In addition, alphasynuclein immunostaining was performed to fully characterize LBP in each case. One-hundred and ten AD and/ or LBP subjects with sufficient clinical and np data were eligible for this study. Results: Cases with np AD and concomitant LBP had the highest frequency of VH, compared to those with AD alone (34% versus 12%, Fisher’s exact test, p .015). VH were present in 28% of subjects with LBP alone. Among LBP cases (n 68) those with limbic LBP have a higher frequency of VH, compared to those with LBP predominantly in the amygdala (42% versus 12%, p 0.045). Although differences were not statistically significant, there is also an indication that, relative to cases with amygdala predominant LBP, cases with brainstem LBP also have greater frequency of VH (43% versus 12%, p 0.126). VH were present in 33% of subjects with neocortical predominant LBP. There was no significant association between Braak NFT staging and presence of VH. Conclusions: In our sample, cases with AD and concomitant LBP have the highest frequency of VH. Within LBP cases, frequencies of VH varied with LBP subtypes. Understanding the pathophysiological bases for the development of VH in LBP is critical in the diagnosis and treatment of patients with DLB.