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O3–06–08: Pattern of amyloid plaque deposition with Pittsburgh compound–B (PIB) in mild cognitive impairment
Author(s) -
DeKosky Steven Trent,
Mathis Chester A.,
Price Julie C.,
Lopresti Brian J.,
Meltzer Carolyn C.,
Ziolko Scott K.,
Hoge Jessica A.,
Tsopelas Nicholas,
Klunk William E.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.239
Subject(s) - pittsburgh compound b , precuneus , posterior cingulate , cognitive impairment , psychology , nuclear medicine , white matter , alzheimer's disease , cardiology , medicine , pathology , cognition , neuroscience , disease , magnetic resonance imaging , radiology
quantified by distribution volume ratio (DVR). Results: Neocortical A deposition was present in 100% of AD subjects, 89% of DLB subjects, 43% of MCI subjects, 18% of elderly controls and no FTD subjects. PIB distribution was similar in AD and DLB, being greatest in medial frontal, precuneus, parietal and lateral temporal cortex, and caudate nuclei. Occipital, sensori-motor and mesial temporal cortex were less affected. Neocortical DVR measured 2.0 0.3 in AD, 1.6 0.3 in DLB, 1.5 0.4 in MCI, 1.2 0.2 in control and 1.1 0.1 in FTD subjects (p 0.01 for all differences). Five of the NC had cortical binding predominantly in frontal cortex with one progressing to MCI at 12-month follow-up. DVR correlated with MMSE and memory impairment across all subjects (r 0.7, p 0.0001) but not within groups (in AD group p 0.16), and with a shorter interval from onset of cognitive impairment to diagnosis in DLB (r 0.9, p 0.002). Conclusions: PIB PET will permit earlier diagnosis of AD and improve differential diagnosis of dementia. Longitudinal follow-up is required to determine the significance of the PIB binding in the normal elderly controls and MCI subjects. Our findings suggest that PIB PET will detect AD before demonstrable cognitive decline and therefore be a useful tool for early intervention trials.