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O1–04–08: Left orbitofrontal atrophy correlates with disinhibition and apathy in frontotemporal degeneration
Author(s) -
Chow Tiffany W.,
Binns Malcolm A.,
Freedman Morris,
Stuss Donald T.,
Ramirez Joel,
Verhoeff Nicolaas P.L.G.,
Black Sandra E.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2335
Subject(s) - apathy , disinhibition , frontotemporal dementia , atrophy , psychology , orbitofrontal cortex , medicine , psychiatry , dementia , disease , cognition , prefrontal cortex
or substantia nigra inclusions were observed. Cases of AD without LBP (AD alone) were selected from the same sample for comparison of clinical features. Results: Nineteen cases fulfilled criteria for AP-LBP. Eighteen of these (95%), had concomitant neuropathological AD. Neuropsychological testing at enrollment revealed no significant differences between AP-LBP and AD alone. However, the rate of decline for the Mini-Mental State Exam (MMSE) was significantly greater in AP-LBP versus AD alone (5.7 vs. 3.6 pts/yr, p 0.05). Examination of MMSE subscores found that this latter finding was due to a greater rate of decline in memory and language performance in AP-LBP cases. Clinically AP-LBP cases had a higher frequency of pacing than AD alone, but similar frequencies of hallucinations and parkinsonism. Conclusions: AP-LBP is observed primarily in cases with concomitant neuropathological AD, although not always in those cases with the most severe AD pathology. Despite limited distribution of LBP in AP-LBP, this change is associated with a more rapid decline of cognitive function, including language. This latter finding suggests AP-LBP may be associated with additional, more anatomically diffuse, neuropathological change.