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IC–P–124: Pharmacological MRI of H3 receptor antagonist GSK189254 in the rat brain
Author(s) -
Cash Diana,
Tilling Lorna,
Barjat Herve,
Debnam Allison,
Njeri Catherine J.,
Briggs Mike A.,
Roberts Jenny C.,
Irving Elaine A.,
Medhurst Andy D.,
Williams Steve C.R.,
Upton Neil,
James Michael F.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2330
Subject(s) - histamine h3 receptor , neuroscience , antagonist , medicine , pharmacology , chemistry , anesthesia , endocrinology , psychology , receptor
ratio, measured in most cases at two levels which were then averaged. Results: Bicaudate and biatrial ratios (mean SD, range) were 0.160 0.038 (0.07-0.26) and 0.242 056 (0.10-0.37). Average decline in mMMS was 3.46 points/year. Using GEE analysis, we found a significant relationship between bicaudate (p 0.001) and biatrial (p 0.007) atrophy scores and the rate of cognitive decline. Decline in mMMS was 0.41 (bicaudate) and 0.19 (biatrial) mMMS points/percentage point of atrophy /year, or about 14% and 18% increased speeds of decline per percentage point of atrophy. These relationships remained significant, even with adjustments for baseline mMMS, age, sex, education, cardiovascular risk factors, and apoE4. Conclusions: Brain atrophy is associated with increased rapidity of cognitive decline in AD. This association does not appear to relate to disease severity at baseline, nor apoE, age, or cardiovascular risk factors. AD may progress at different rates in different individuals.