Premium
IC–P–119: An integrated framework for computational neuroanatomy: Comparing cortical thickness against manual tracing of the hippocampus
Author(s) -
Zijdenbos Alex P.,
Lerch Jason P.,
Evans Alan C.,
Schuff Norbert,
Weiner Michael W.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2325
Subject(s) - entorhinal cortex , atrophy , hippocampal formation , hippocampus , neuroimaging , brain size , cortex (anatomy) , neuroscience , neuroanatomy , medicine , nuclear medicine , magnetic resonance imaging , psychology , radiology
criteria. Ten-year stroke risk was calculated using a modified version of the Framingham Stroke Risk Profile. The associations between MRI measures and “progression” from CDR 0 to CDR 0.5, or “conversion” from CDR 0.5 to incident dementia, were evaluated in separate Cox proportional hazards models. Models were adjusted for age, sex, education, APOE genotype, vascular risk factors and, for analyses of subjects with baseline MCI, CDR sum of boxes at baseline. Results: Within a mean follow up of 6.3 4.1 years, progression from CDR 0 to CDR 0.5 was seen in 26/67 subjects, and conversion from CDR 0.5 to dementia was seen in 54/156 subjects. WMHr was a predictor of progression (adjusted HR 1.68, 1.13-2.51, p 0.01) but not conversion (adjusted HR 0.93, 0.721.20, p 0.58). Conversely, CSFr did not predict progression (adjusted HR 1.04, 0.94-1.15, p 0.47), but did predict conversion (adjusted HR 1.12, 01.03-1.20, p 0.005). Among those with MCI at baseline, each 1% increase in predicted 10-year stroke risk was associated with a 1.07-fold increased hazard of dementia (1.03-1.11, p 0.0003) in a multivariable model. Analyses limiting the dementia outcome to AD alone (45 cases) had essentially the same results. Conclusions: These findings suggest that WMH may interfere with cognitive function but may not be sufficient to produce dementia. In persons whose cognitive abilities are already impaired, a global measure of brain atrophy is more predictive of conversion to dementia. Persons at increased risk of stroke are also at increased risk of dementia.