IC–P–106: Behavioral findings and magnetic resonance imaging in aged macaques: Modeling AD? | Zendy

Fernández Caridad I. | Zendy; Rodriguez-Rojas R. | Zendy; Carballo M. | Zendy; Álvarez L. | Zendy

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IC–P–106: Behavioral findings and magnetic resonance imaging in aged macaques: Modeling AD?

Author(s) -

Fernández Caridad I.,

Rodriguez-Rojas R.,

Carballo M.,

Álvarez L.

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.2312

Subject(s) - psychology , atrophy , neuroscience , audiology , magnetic resonance imaging , memory impairment , macaque , cognition , medicine , pathology , radiology

showed change in activation that correlated with MMSE. Conclusions: In preliminary analyses of a blinded AD clinical trial, change in performance on standardized memory measures correlated with change in fMRI activation. Furthermore, cross-modal associative memory-related activations demonstrated regionally specific changes in medial temporal lobe and neocortical areas associated with domain specific memory performance. These results support the validity of fMRI as a potentially sensitive biomarker for assessing signals of efficacy in early-stage AD clinical trials. Monitoring progression of Alzheimer’s disease and related disorders.

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