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IC–P–101: Automatic calculation of hippocampal atrophy rates using the boundary shift integral
Author(s) -
Barnes Josephine,
Boyes Richard G.,
Lewis Emma B.,
Schott Jonathan M.,
Bartlett Jonathan W.,
Frost Chris,
Scahill Rachael I.,
Fox Nick C.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2307
Subject(s) - segmentation , atrophy , automated method , hippocampal formation , boundary (topology) , hippocampus , pattern recognition (psychology) , medicine , artificial intelligence , computer science , nuclear medicine , mathematics , mathematical analysis
cortex and the hippocampus. The obtained spectra were analyzed using LCModel, and the quantification was obtained using tCr resonance as an internal standard. Conclusions: Levels of mIns are higher for APP-PS1, compared to wild-type, APP and PS1 mice but do not differ between wild-type, APP and PS1 mice. The taurine levels are higher for APP than for APP-PS1, PS1 and wild-type mice but do not differ between wild-type, APP-PS1 and PS1 mice. The elevation in taurine in only the APP mice would indicate that the neurochemical alteration in these mice is not a function of amyloid plaque burden; because, at a similar age of roughly 600 days, the plaque load is greater in APP-PS1 mice which do not exhibit elevated levels of taurine. The fact that APP mice do exhibit an increase in taurine while APP-PS1 mice do not indicates that the taurine increase cannot simply be due to the presence of the APP mutation alone in the mouse genome.