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IC–P–096: Treatment of mild cognitive impairment with vitamin E and donepezil: Correlations between serial MRI and conversion, genotype, and treatment status
Author(s) -
Thal Leon J.,
Jack Clifford R.,
Grundman Michael,
Ward Chadwick,
Sencakova Drahomira,
Jin Shelia,
Gamst Anthony,
Petersen Ronald C.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2300
Subject(s) - atrophy , medicine , donepezil , temporal lobe , entorhinal cortex , cardiology , hippocampus , neurology , magnetic resonance imaging , nuclear medicine , dementia , radiology , psychiatry , disease , epilepsy
AD 42.0 27.3. 3). Transfer function gain at 0.05 Hz increased with early AD: young 3.1 0.5, aging 3.4 0.5, AD 3.9 1.7 units. Conclusions: CBFV was reduced with aging and further reduced in AD. The preliminary data suggest that in early AD, dynamic CA is impaired. In addition, enhanced fluctuations in ABP and CBFV suggest the presence of instability of the systemic and cerebral circulation. These findings point towards an increased risk for transient brain ischemia during daily life in AD.