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IC–P–087: Annualized decrease in plasma Aβ42 correlates with annualized decrease in hippocampal volume
Author(s) -
Graff-Radford Neill R.,
Weigand Stephen D.,
Shuing Maria M.,
Knopman David S.,
Boeve Bradley F.,
Lucas John A.,
Crook Julia E.,
Younkin Linda H.,
Petersen Ronald C.,
Jack Clifford R.,
Younkin Steven G.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2292
Subject(s) - hippocampal formation , medicine , cohort , atrophy , population , cardiology , gastroenterology , endocrinology , environmental health
degree of RvF activation, such that greater impairment was associated with greater left hippocampal (-34,-20,-20; z 2.80, p 0.003) activation to Repeated stimuli. Conclusions: These findings suggest that hippocampal responses to repeated stimuli are distinctly altered in AD and also in more impaired MCI subjects. Failure of habituation to repeated stimulus exposure may prove to be a sensitive marker of hippocampal dysfunction due to AD pathology. Research supported by NINDS K23-NS02189; NIA PO1AG04953; NIA P50-AG00513421; Academy of Finland.