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IC–P–076: Patterns of age–related reduced cerebral blood flow and diminished white matter integrity by high–field perfusion and diffusion MRI
Author(s) -
Schuff Norbert,
Zhang Yu,
Du Antao,
Mueller Susanne,
Hlavin Jennifer,
Jahng Geonho,
Stables Lara,
Cashdollar Nate,
Weiner Michael W.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2281
Subject(s) - white matter , corpus callosum , fractional anisotropy , cerebral blood flow , cingulum (brain) , diffusion mri , psychology , cardiology , medicine , posterior cingulate , magnetic resonance imaging , neuroscience , cortex (anatomy) , radiology
connectivity between the right middle FG and all other voxels in the brain. Results: Task performance was not statistically different between groups. There was no statistically significant difference in activation between groups. The right middle FG of the HC and MCI groups had strong positive linear correlation bilaterally to the visual cortex, inferior and superior parietal lobules, dorsolateral prefrontal cortex (DLPFC) and anterior cingulate. The HC group had higher positive linear correlation of the right middle FG to the visual cortex, parietal lobes and right DLPFC compared to the MCI. The MCI had higher positive linear correlation to the cuneus and inferior parietal lobule. In both groups the right middle FG had negative linear correlation to inferior parietal lobules and medial temporal regions and additionally in the HC to the medial frontal areas. In the negatively linearly correlated regions, the MCI group had smaller functional connectivity to the medial frontal areas compared to the HC because there was no linear correlation in the MCI group. Conclusions:The putative presence of Alzheimer’s disease (AD) neuropathology in MCI affects functional connectivity from the right middle FG to the visual areas and medial frontal areas. In addition, higher linear correlation in the MCI group in the parietal lobe may indicate the initial appearance of compensatory processes. Functional connectivity can be an effective marker for detecting functional changes in MCI subjects.