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IC–P–071: The effect of APOE–4 on fMRI deactivation in older controls, MCI subjects and AD patients
Author(s) -
Pihlajamaki Maija,
Miller Saul M.,
DePeau Kristina M.,
Celone Kim A.,
Bertram Lars,
Tanzi Rudolph E.,
Dickerson Bradford C.,
Albert Marilyn S.,
Blacker Deborah,
Sperling Reisa A.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2276
Subject(s) - posterior cingulate , apolipoprotein e , retrosplenial cortex , default mode network , psychology , medicine , audiology , functional magnetic resonance imaging , neuroscience , disease , cortex (anatomy)
who progressed to AD after follow-up period (CDR 1; 11 patients; 7 women, 4 men) and second group consisted of patients who had stable symptoms of MCI (CDR 0.5; 8 patients; 3 women, 5 men). The relationship between hippocampal volume z-score and the risk of developing AD over a two-year period of observation adjusted for age and sex interaction in logistic regression model was Rsquare 0.65; p 0.045 for left hippocampus and Rsquare 0.56; p 0.055 for right hippocampus. Conclusions: Initial hippocampal volume may influence the dynamics of cognitive decline in MCI patients over a two-year period of observation. The difference of effect between sides suggests higher sensitivity of left hippocampal volume as a predictive marker of AD. However lack of normative values of hippocampal volume mean and SD for elderly population limits calculated z-score to studied population.