IC–P–071: The effect of  APOE–4  on fMRI deactivation in older controls, MCI subjects and AD patients | Zendy

Pihlajamaki Maija | Zendy; Miller Saul M. | Zendy; DePeau Kristina M. | Zendy; Celone Kim A. | Zendy; Bertram Lars | Zendy; Tanzi Rudolph E. | Zendy; Dickerson Bradford C. | Zendy; Albert Marilyn S. | Zendy; Blacker Deborah | Zendy; Sperling Reisa A. | Zendy

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IC–P–071: The effect of APOE–4 on fMRI deactivation in older controls, MCI subjects and AD patients

Author(s) -

Pihlajamaki Maija,

Miller Saul M.,

DePeau Kristina M.,

Celone Kim A.,

Bertram Lars,

Tanzi Rudolph E.,

Dickerson Bradford C.,

Albert Marilyn S.,

Blacker Deborah,

Sperling Reisa A.

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.2276

Subject(s) - posterior cingulate , apolipoprotein e , retrosplenial cortex , default mode network , psychology , medicine , audiology , functional magnetic resonance imaging , neuroscience , disease , cortex (anatomy)

who progressed to AD after follow-up period (CDR 1; 11 patients; 7 women, 4 men) and second group consisted of patients who had stable symptoms of MCI (CDR 0.5; 8 patients; 3 women, 5 men). The relationship between hippocampal volume z-score and the risk of developing AD over a two-year period of observation adjusted for age and sex interaction in logistic regression model was Rsquare 0.65; p 0.045 for left hippocampus and Rsquare 0.56; p 0.055 for right hippocampus. Conclusions: Initial hippocampal volume may influence the dynamics of cognitive decline in MCI patients over a two-year period of observation. The difference of effect between sides suggests higher sensitivity of left hippocampal volume as a predictive marker of AD. However lack of normative values of hippocampal volume mean and SD for elderly population limits calculated z-score to studied population.

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