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IC–P–052: Increased activation in the fusiform gyrus during picture encoding in subjects with mild cognitive impairment
Author(s) -
Hämäläinen Anne,
Pihlajamäki Maija,
Hänninen Tuomo,
Tanila Heikki,
Niskanen Eini,
Tervo Susanna,
Karjalainen Pasi A.,
Vanninen Ritva L.,
Soininen Hilkka
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2257
Subject(s) - fusiform gyrus , cognitive impairment , neuroscience , psychology , cognition
disease. However, no study has analyzed the potential association between Age-Related White Matter Hyperintensities (ARWMH) load and the CC area in non-disabled elderly subjects with leukoaraiosis. Objectives: The aim of this study was to investigate whether ARWMH load in specific brain regions predicts the size of CC. Methods: The population consisted of 578 non-disabled elderly subjects (age: 64-85, F/M: 313/265) with ARWMH from the European Leukoaraiosis And DISability multicenter study (LADIS). High-resolution 1.5 T, sagittal MPRAGE images of the brain were performed in all subjects. Cross-sectional area of the CC was then automatically localized and delineated on the mid-sagittal slice of the stereotactically and normalized MPRAGE images. Each CC area was subdivided into five regions: rostrum and genu, rostral body, midbody, isthmus and splenium. The ARWMH was measured quantitatively with a semi-automated volumetric technique and automatically segmented into six brain regions (frontal, parietal, occipital, temporal, basal ganglia and infratentorial). ARWMH volume of each region was calculated. The correlation between the size of CC subregions and the ARWMH load was examined for all brain regions using the general linear model (GLM) with correction for age, gender, handedness, infarcts and regional lacunes. Results: The mean total CC area was 643 135 mm and the mean volume of ARWMH was 24.0 25.0 ml. Most ARWMH were found in the frontal lobe region (14.7 15.3 ml). Except for the midbody, there was significant correlation between the area of all CC subregions and the ARWMH load in four or more of the six brain regions. Furthermore, there was a significant correlation between the total CC area and the total ARWMH load (r -0.273; p 0.001). Conclusions: We found significant correlations between the severity of ARWMH load in specific brain regions and the size of CC. We conclude that ARWMH load is a good predictor of CC atrophy in non-disabled elderly subjects with leukoaraiosis.