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IC–P–049: A novel quantitative analysis method of β–amyloid plaques in model mice of Alzheimer's disease using a phase–contrast X–ray imaging technique
Author(s) -
Yoneyama Akio,
Noda-Saita Kyoko,
Shitaka Yoshitsugu,
Takeda Tohoru,
Hyodo Kazuyuki,
Hirai Yasuharu
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2254
Subject(s) - contrast (vision) , phase contrast imaging , quantitative analysis (chemistry) , phase contrast microscopy , materials science , pathology , biomedical engineering , nuclear medicine , chemistry , nuclear magnetic resonance , optics , medicine , physics , chromatography
non-AD dementia were excluded, HPV and ERCV predicted the progression to AD, but the CDR-SB was not a significant predictor. In the group of carriers of ApoE 4 allele, progressive MCI subjects had significantly reduced HPV and ERCV compared to stable MCI subjects. There were no differences in volumes between the stable and progressive MCI groups without 4 allele. Conclusions: This study supports the use of MRI scan for volumetric assessment of HP and ERC in elderly subjects with memory problems to assess the risk of progression to dementia. Although not a significant predictor of dementia, the effect of ApoE 4 allele was clearly seen on the medial temporal lobe morphology in MCI subjects. Acknowledgements: The study was supported by the Research Council for Health of the Academy of Finland, and an EVO grant 5772720 from the Kuopio University Hospital.