IC–P–037:  In vivo  targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques | Zendy

Poduslo Joseph F. | Zendy; Holasek Silvina | Zendy; Ramakrishnan Muthu | Zendy; Ramirez-Alvarado Marina | Zendy; Gilles Emily | Zendy; Curran Geoffry L. | Zendy; Wengenack Thomas M. | Zendy

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IC–P–037: In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques

Author(s) -

Poduslo Joseph F.,

Holasek Silvina,

Ramakrishnan Muthu,

Ramirez-Alvarado Marina,

Gilles Emily,

Curran Geoffry L.,

Wengenack Thomas M.

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.2242

Subject(s) - in vivo , immunotherapy , amyloid β , antibody , amyloid (mycology) , molecular imaging , medicine , pathology , alzheimer's disease , disease , central nervous system , chemistry , immunology , immune system , biology , microbiology and biotechnology

patients (mild and moderate AD). We observed correlation between Naa/Cr and mI/Naa ratios in the posterior cingulate with the MMSE, being a positive correlation with Naa/Cr and negative correlation with mI/Naa. Conclusions: There was no advantage in performing MRS in the hippocampi instead of posterior cingulate, a technically challenging location, usually leading to a longer examination time, specially if taken into account the demential state of the patients, being desirable the shortest time of examination possible.

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