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IC–P–037: In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques
Author(s) -
Poduslo Joseph F.,
Holasek Silvina,
Ramakrishnan Muthu,
Ramirez-Alvarado Marina,
Gilles Emily,
Curran Geoffry L.,
Wengenack Thomas M.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2242
Subject(s) - in vivo , antibody , genetically modified mouse , polyamine , central nervous system , antigen , pathology , immunotherapy , transgene , chemistry , monoclonal antibody , microbiology and biotechnology , medicine , immunology , cancer research , biology , neuroscience , biochemistry , immune system , gene
patients (mild and moderate AD). We observed correlation between Naa/Cr and mI/Naa ratios in the posterior cingulate with the MMSE, being a positive correlation with Naa/Cr and negative correlation with mI/Naa. Conclusions: There was no advantage in performing MRS in the hippocampi instead of posterior cingulate, a technically challenging location, usually leading to a longer examination time, specially if taken into account the demential state of the patients, being desirable the shortest time of examination possible.