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IC–P–027: The evidence of neural network disruption in mild cognitive impairment – MR diffusion tensor imaging study
Author(s) -
Okumura Ayumi
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2232
Subject(s) - fornix , cingulum (brain) , corpus callosum , white matter , diffusion mri , psychology , fractional anisotropy , external capsule , tractography , neuroscience , medicine , magnetic resonance imaging , pathology , hippocampus , radiology
pared to FTD, AD was associated with thinner cortices in parietal regions, precuneus and posterior cingulate (p 0.01). Compared to AD, FTD was associated with thinner cortices in orbitofrontal regions (p 0.01). In general, cortical thickness provided no significant advantage over the corresponding volumes in classifying AD from CN and FTD. However, cortical thickness of parietal and temporal lobes (area under the ROC curve (AUC): 0.70-0.95 95% confident interval) showed a trend (p 0.06) to better separate FTD from CN than the corresponding volume (AUC: 0.54-0.86). Conclusions: The characteristic patterns of cortical thinning in AD and FTD seen on MRI are consistent with pathological findings. Furthermore, cortical thinning may be a more prominent feature than volume loss for separating FTD from normal aging.