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IC–P–024: MRI, MRS and clinical correlates in posterior cortical atrophy and typical Alzheimer's disease
Author(s) -
Whitwell Jennifer L.,
Jack Clifford R.,
Kantarci Kejal,
Boeve Bradley F.,
Knopman David S.,
Drubach Daniel A.,
Tang-Wai David F.,
Petersen Ronald C.,
Josephs Keith A.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2229
Subject(s) - posterior cortical atrophy , atrophy , dementia , voxel , temporal lobe , parietal lobe , psychology , voxel based morphometry , occipital lobe , posterior parietal cortex , grey matter , alzheimer's disease , neuroscience , medicine , pathology , magnetic resonance imaging , white matter , disease , radiology , epilepsy
between both groups were found in delayed memory and recognition of non-presented words (DLB PDD p corrected 0.05) and in the perseverations of the Continuous performance Test and Symbolic Gesture (PDD DLB p corrected ’0.05). Moreover, there is a trend towards signification of the verbal learning task (table 4). Conclusions: 1. Subjects with DLB show greater gray matter atrophy than those with PDD of similar degree of dementia. 2. DLB patients have more gray matter reduction in both precentral gyrus than PDD. 3. DLB patients have significantly smaller volumes of left middle frontal lobe compared to PDD. 4. Neuropsychologically, PDD patients have more fronto-parietal impairment and DLB patient more memory dysfunctions.